Hysterectomy, non-malignant gynecological diseases, and the risk of incident hypertension: The E3N prospective cohort

Objectives While it has been reported that women with uterine fibroids or endometriosis are commonly overweight and hypertensive, the association between non-malignant gynecological diseases risk of hypertension little studied prospectively. The aim this study was to investigate in a large French cohort whether history hysterectomy, fibroids, prospectively related an increased incident hypertension. Study design We analyzed 50,286 from E3N who were free at baseline, median follow-up 16.4 years. Main outcome measures Gynecological based on self-report. Cox proportional hazards models age as timescale used estimate hazard ratios (HRs) 95% confidence intervals (CIs). Covariates included smoking status, body mass index (BMI), physical activity, hormonal factors. Results A total 12,073 (24%) developed during follow-up. Women hysterectomy had hypertension, which persisted after adjustment for potential confounding factors (adjusted HR=1.18, CI 1.12–1.24). Risk similar without oophorectomy. higher (HRendometriosis 1.19, 95%CI 1.11–1.22) (HRfibroids 1.18, 1.13–1.22), irrespective hysterectomy. Associations further BMI. Conclusions Hysterectomy associated prospective study. these conditions may benefit blood pressure monitoring. ClinicalTrials.gov identifier: NCT03285230